- Ankylosing Spondylitis
- Cerebral Palsy
- Charcot-Marie-Tooth Disease (CMT)
- Crohn's Diseases
- Guillain-Barre’ Syndrome
- Hashimoto's Thryroiditis
- Kidney Diseases
- Myasthenia Gravis
- Macular Degeneration
- Lupus (SLE)
- Multiple Sclerosis
- Psoriatic Arthritis
- Parkinson’s disease
- Rheumatoid Arthritis
- Ulcerative Colitis
Autism Spectrum Disorder (ASD) –Stem Cell Therapy
-Autism spectrum disorder (ASD)
Autism Spectrum Disorder (ASD) Characteristics
Autism spectrum disorder (ASD) includes individuals with a range of symptoms, abilities, and levels of impairment. Some children with autism are very high-functioning, communicating with others and performing well at school, while others experience significant impairment and remain highly dependent on caregivers.
Exact traits may vary by child, but autism is characterized by the following symptoms:
• Social impairment. Kids with autism tend to make less eye contact, fail to respond to people in their environment, avoid sharing enthusiasm about activities by pointing or showing toys to others, and have atypical responses to others’ emotions. They often fail to reciprocate others’ emotions and avoid interacting socially with peers or adults.
• Communication difficulties. For many children with autism, communication abilities remain a challenge. Early signs of autism include failure to develop age-appropriate gestures (e.g., pointing or waving), slowness in responding to their name, and a sudden stop in babbling after age one. Children show general language delays, having difficulty using complete sentences, substituting special made-up words in conversation, or repeating the same phrase over and over.
• Repetitive behaviors. One of the hallmark symptoms of autism spectrum disorder is repetitive behaviors. This might include hand flapping, rocking, or finger flicking. Some children with autism may develop highly focused interests that have an obsessive quality. For example, some kids feel driven to learn as much as possible about trains, dinosaurs, or Star Trek. Interrupting these preoccupations, such as moving a favorite toy train, can be extremely upsetting for a child with autism.
Neurological and Physiological Changes
Researchers continue to explore the neurobiological changes associated with ASD. MRI studies have found that children with autism have some brain areas that are larger than neurotypical children, while other brain areas are smaller. During development, abnormal neuronal growth and problems with pruning of growing neurons may contribute to these differences.
Specifically, many children with autism have changes in the temporal lobe. This lobe is important for language processing, attention, empathy, facial processing, and social abilities. Changes in the structure and function of the temporal lobe may underlie autistic kids’ difficulties connecting socially, showing appropriate emotions, and communicating with others.
A recent study has also found that brain chemicals differ between neurotypical children and those with ASD. In early childhood, kids with autism have lower levels of an important brain chemical called N-acetylaspartate (NAA). NAA is thought to help with efficient nerve impulse transmission and the creation of connections between neurons.
Two recurring conditions associated with autism spectrum disorder are decreased oxygenation to certain areas of the brain and gastrointestinal problems. Many researchers believe that immune system dysfunction may contribute to these issues, providing a potential treatment target addressed by stem cell therapy.
Causes of Autism Spectrum Disorder
Understanding the causes of autism spectrum disorder is an ongoing effort by research scientists worldwide. Although the causes of autism remain poorly understood, some clues exist.
1) Genetic factors. While specific genes have not been characterized, genetic risk factors play a role in the development of autism. A child who has siblings with autism is more likely to be diagnosed with the disorder. Furthermore, autism rates are higher among people with certain genetic disorders, including untreated phenylketonuria (PKU) and Fragile X syndrome.
2) Prenatal environment. Environmental factors occurring before birth may increase autism risk. For example, viral infections during pregnancy, congenital rubella, gestational diabetes, obesity, and exposure to alcohol or drugs may increase the likelihood that a child develops autism.
3) Postnatal environment. After birth, several factors may increase the risk of autism. Exposure to heavy metals, gastrointestinal problems, metabolic imbalances, changes in detoxification pathways, and autoimmune diseases may contribute to autism risk. The popular media has reported about the connection between vaccines and autism, and there are twenty-two small studies supporting this link. However, controlled studies have provided no convincing scientific evidence to support the vaccine-autism connection.
How Can Stem Cell Treatment Help? Autism spectrum disorder (ASD)
Purpose of Stem Cell Therapy
Stem cell therapy is a new advance in the treatment of autism spectrum disorder. At World Stem Cells Clinic in Cancun, experienced physicians perform a comprehensive assessment of your child’s condition and recommend individualized treatment plans. In addition to performing the typical behavioral and biomedical treatment approaches for autism, stem cells are used to restore normal functioning. World Stem Cells Clinic uses the ATEC form, which has been used to evaluate ASD youngsters for both staging and statistically relevant changes. It has a history dating back to 2000, with continued relevance for anyone wishing to evaluate the level of symptom change following a therapy.
Clinical research studies suggest that using stem cells from bone marrow, adipose and other sources selected may address metabolic problems that contribute to ASD. Many children with autism have immunological problems, gastrointestinal issues, and increased inflammation. With stem cell therapy, these problems can be addressed to reduce autism symptoms, as we have seen in many of our patients.
Treatment Outcomes Autism spectrum disorder (ASD)
After stem cell therapy at World Stem Cells Clinic, patients show improvements in perception, cognitive abilities, and fine motor skills. This may address several of the problems seen in children with autism, including social impairment and repetitive behaviors. World Stem Cells Clinic has seen the following improvements following stem cell therapy:
1. Improved digestion and a decrease in inflammatory problems.
2. Better tolerance to a variety of foods. Many children start trying new foods and liking them.
3. Improvements in behavior at home, school, and elsewhere.
4. Better quality and easier contact with the child (including improved eye contact and attention span). Children start looking at objects with interest.
5. Improved self-care skills, including ability to dress themselves and be potty trained.
6. Eating with utensils instead of the hands.
7. Diminished or no fear of loud noises, strangers, and bright colors
8. Children that are non-verbal begin making sounds, pronouncing syllables, and saying words. Non-verbal children develop larger vocabularies.
9. Development or improvement in writing skills.
10. Better sleeping habits
11. Improved attention span, concentration and interaction with other people.
12. A new life and hope for the family wanting their children to be self sufficient when they grow up.
HELP US HELP THEM!
Each patient undergoes a thorough assessment for stem cell therapy by trained medical staff, resulting in an individualized treatment plan that addresses any special needs. A typical course of treatment includes:
Our physicians conduct a thorough physical, behavioral, and psychological assessment. We will collect a small blood sample and administer cell expansion medication. After we answer any questions and address relevant concerns, you will return to your hotel for a good night’s sleep.
Our physicians will review the laboratory results to determine whether your cell count is in the appropriate range. Depending on the results, you may undergo cell harvesting and processing. If your cell count is not adequate, we will provide additional medications or treatments to increase cell count.
Board certified specialists physicians will harvest a bone marrow or adipose sample. Children and adolescents typically receive general anesthesia, while adults use local anesthetics. Although you may feel some pain upon needle insertion, the entire procedure takes just 30 minutes and is generally pain-free. After the procedure, you may return to the hotel, with some restrictions. The bone marrow or adipose sample is processed in our state-of-the-art laboratory by trained staff supervised by a lab physician. Depending on your individualized treatment plan, umbilical cord blood may be used as an alternative to the above procedure.
You will be treated by IV infusion and/or a lumbar puncture. These procedures inject the stem cells into the cerebrospinal fluid, allowing them to travel through the spinal canal directly into the brain. This eliminates restrictions imposed by the blood-brain barrier, increasing the efficacy of the stem cell therapy. You may be required to spend the day at the hospital or hotel, restricting your activities.
Our physicians will conduct a thorough post-treatment examination and evaluate you prior to your release. We may employ additional ancillary treatments to maximize the effectiveness of the stem cell therapy.
What Makes Our Treatment Unique?
Unlike typical approaches to autism spectrum disorder treatment, which rely on psychological methods and medications that may be ineffective or cause side effects, our stem cell approach addresses what we think may be the root problems of autism. Prior to collection of the cells, we stimulate growth and assess the implantation potential of your sample. This ensures that you will receive the best possible outcomes, making a positive impact on your condition. Furthermore, our staff physicians are board-certified and have decades of experience in their specialties.
Your experience at World Stem Cells Clinic includes an open registry to monitor your treatment progress, information about the latest advances in stem cell research, and future assessments to evaluate your treatment gains. This is not just a one-stop treatment — it is an ongoing relationship designed to help each patient experience improvement in his or her spectrum of dysfunction. Furthermore, we offer bilingual staff members, travel support, and excellent lodging options to make your stay as comfortable as possible. Our research-based treatment, world class physicians, and exceptional standards for patient care set World Stem Cells Clinic apart.
1. Ichim, T.E., et al. (2007). Stem cell therapy for autism. Journal of Translational Medicine 5(3). http://www.cellmedicine.com/wp-content/uploads/2012/11/Stem-Cell-Therapy-for-Autism.pdf
2. Levy, S.E., Mandell, D.S., & Schultz, R.T. (2009). Autism. Lancet 374(9701). http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61376-3/abstract
3. Johnson, C.P. & Myers, S.M. Identification and evaluation of children with autism spectrum disorders. Council on Children with Disabilities.
4. Mohamed, A.A., et al. (2006). Ex vivo expansion of stem cells: Definition optimum conditions using various cytokines. Laboratory Hematology 12, 86-93.
5. Arndt, T.L., Stodgell, C.J., & Rodier, P.M. (2005). The teratology of autism. International Journal of Developmental Neuroscience 23(23).
6. Plumas, J., et al. Mesenchymal stem cells induce apoptosis of activated T cells. (2005) Leukemia 19, 1597-1604.
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